The highest score ever achieved in a single move in a game of Scrabble was discovered by Dan Wood in 2008. It required an unlikely scenario with seven letters, and a board that looked like this:
O-pacifyingX-sizeRe-qualifiedRain-washingAwakenersOne-timeEjaculating
By playing the letters vertically, the word oxyfinbutazone was formed, which is allowed in tournament play by the North American Scrabble Players Association. This one move scored an incredible 1780 points!